Curcumin and Fermented Soy Capsules and Fermented Soy/Curcumin Nutritional Beverage Studies that used the Jiva Ingredient: Curcumin C3 Complex® Inflammatory Bowel Disease

• Numerous therapies used for inflammatory bowel disease (IBD) target the transcription factor NFkappaB, which is involved in the production of cytokines and chemokines integral for inflammation. The authors show that curcumin, is able to attenuate colitis in the dinitrobenzene sulfonic acid (DNB)-induced murine model of colitis. They also show that the immunohistochemical signal is dramatically attenuated at the level of the mucosa by curcumin. They conclude that curcumin is able to attenuate experimental colitis through a mechanism correlated with the inhibition of the activation of NF-kappaB and effects a reduction in the activity of p38 MAPKwith therapeutic implications for human IBD.